PAX6 REGULATES NEURONAL MIGRATION AND CELL PROLIFERATION VIA INTERACTING WITH WNT3A DURING CORTICAL DEVELOPMENT

Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical development

Abstract The paired box 6 (Pax6) gene encodes a highly conserved transcription factor, involved in the development of eyes, brain, and endocrine glands.Homozygous loss of Pax6 resulted in neonatal death in mice, plus loss of eyes and malformation of cerebral cortex.In patients with heterozygous Pax6 mutations, a reduction in thickness of the fronto

read more